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These pathways are highly relevant to HS pathogenesis, which involves dysregulated innate immunity, chronic inflammation, and oxidative damage

Toll-like receptor 2 promotes breast cancer progression and resistance to chemotherapy

It is worth noting that for currently licensed GLP-1 receptor agonists in the UK, the thyroid tumour signal is classified as a precautionary consideration based on rodent data, rather than a formal contraindication as reflected in UK Summaries of Product Characteristics (SmPCs)

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However, early findings suggest that Retatrutide may offer slightly greater weight loss on average, with up to 24% of body weight lost compared to around 20% with Mounjaro