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Senomorphics: Modulating the Senescence-Associated Secretory Phenotype (SASP) Unlike senolytic therapies that aim to directly eliminate senescent cells, senomorphics work by modulating the senescence-associated secretory phenotype (SASP), which consists of pro-inflammatory cytokines, chemokines, growth factors, and extracellular matrix-degrading enzymes secreted by senescent cells
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The field is moving: search interest in this category has grown over 300% year-over-year, and the TB-500 and BPC-157 PCAC review scheduled for July 23-24, 2026 may shift the compounding landscape before year end
Researchers are currently studying whether certain peptides may help regulate neurotransmission, immune responses, mitochondrial activity, and sleep cycles all of which can be affected in ASD
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