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when present, symptoms typically reflect underlying conditions such as liver disease, haematological disorders, or renal impairment rather than the elevated vitamin itself

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doi:10.1093/eurheartj/ehae001 Avis SR, Vernon ST, Hagstrom E, Figtree GA

A number of dosage protocols appear in the epithalamin and epithalon studies and trials performed to date, the most notable of which has been the Khavinson protocol (or, Russian protocol) for anti-aging and longevity [1]