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[Wadden STEP 3, JAMA 2021] STEP 5 Trial (Nature Medicine 2022) Long-term data: patients maintained an average 15.2% weight loss over 2 years of continuous semaglutide use, with sustained metabolic improvements including reduced HbA1c, blood pressure, and waist circumference

When myelin is stripped away, the brain, spinal cord, and peripheral nerves all take damage

both endogenous (ROS) and exogenous (mercury and persistent organic pollutants)

Follow-up care helps monitor progress, medication tolerance, side effects, and whether treatment adjustments may be needed

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