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It simultaneously activates both receptor pathways, producing additive effects on insulin secretion, glucagon suppression, and appetite regulation that exceed what GLP-1 agonism alone achieves
Consequently, IGF-1 LR3 has improved biological potency and extended half-life
62 Figure 5: Network of trials for NMA for third line Figure 5 has been redacted at the sponsors request
Figure 1 summarizes a conceptual overview rather than a single experimental model, developed on the basis of published evidence, with the aim of facilitating the understanding of central and peripheral pathways involved in the GI effects associated with GLP-1 receptor agonists
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