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Caution should be taken with those that have megaloblastic anemia as B12 can reduce potassium levels in the blood

If you have a Vitamin B12 deficiency and pernicious anaemia which disrupts your ability to absorb B12 from your food, regular intramuscular injections of Vitamin B12 will bypass the need for gut absorption and deliver the vitamin directly into your bloodstream

2023 Jan 28;12(3):1002

That changed after chemist Bruce Merrifield developed solid-phase peptide synthesis, a breakthrough that earned him the Nobel Prize in 1984 and dramatically simplified production of these fragile biomolecules by allowing them to be built much more efficiently compared to purification