Disrupted BBB and the blood-cerebrospinal fluid barrier are evident in both sporadic and familial ALS, occurring before the onset of motor neuron degeneration (Fig
Nasal spray delivery Nasal spray delivery offers an alternative route that avoids both the skin barrier and digestive degradation
These experimental findings are used to describe the compounds disposition and biotransformation pathways.1,4 Published pharmacokinetic literature describing the elimination half-life of intravenous alpha-lipoic acid in humans is limited, and formal half-life values are not well established
But a growing body of research, and a wave of real-world experience, suggests these drugs may have meaningful benefits for people with T1D too: lower daily insulin doses, flatter glucose curves on your CGM, and potentially better long-term protection for your heart and kidneys
The gene expression data from Pickart and colleagues provides the most compelling mechanistic context here