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First, it has been shown that in DA-resistant tumors the reduction of DRD2, previously associated with resistance, is accompanied by a low level of FLNA (81)

Nonetheless, administering a VEGF-upregulating compound to individuals with diagnosed or undiagnosed malignancies remains contraindicated based on precautionary clinical reasoning

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The latter was achieved mainly through the gutbone axis by upregulating SESN2 expression in the knee joint, maintaining chondrocyte activity, and mitigating synovial inflammation

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