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doi: 10.3390/nu15061382 19 CorriganMOrourkeAMMoranBFletcherJMHarkinA

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Why Side Effects Occur And Why Timing Varies Stimulation of GLP-1 and GIP affects: Nausea centers Gastric emptying Bowel motility Appetite control Dose size, how fast a clinician escalates the dose, prior gut sensitivity, other medicines, age, kidney function, and metabolic health all change how someone responds

When semaglutide was discontinued after 3 years and all differences in risk factors between the treatment arms were abolished, semaglutide was associated with smaller clinical benefits compared with the base case and increased costs, as differences between the treatment arms were maintained for only 3 years

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