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[2] Nitrous oxide overdose or overuse converts the active monovalent form of vitamin B 12 to the inactive bivalent form

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Clinical trials confirmed no effect on serum IGF-1 levels, no negative effect on carbohydrate metabolism, and no anti-AOD-9604 antibodies detected in any participants

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No, you cannot overdose on B12 It is highly unlikely that someone could take too much B12, says Natalie Allen, RD, a clinical assistant professor of biomedical sciences at Missouri State University