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Building upon this, Tirzepatide , a dual GIP and GLP-1 receptor agonist, has shown even more pronounced effects, with participants in the SURMOUNT-1 trial achieving mean weight reductions of 15.0% to 20.9% at 72 weeks, and a notable proportion (up to 57%) experiencing a weight reduction of 20% or more at the highest dose

For example, in the STEP trials with semaglutide, participants lost up to 17% of their body weight over 68 weeks

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