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Itaconate promotes Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) activation and, subsequently, an anti-inflammatory phenotype in macrophages [245]

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Notably, at higher doses (such as 12 mg once weekly), mean weight loss exceeding 20% of body weight was observed in adults with obesity over approximately 48 weeks

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The drug may aggravate abdominal symptoms in patients with inflammatory bowel disease, notably ulcerative colitis

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