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PMID: 25044089
On the one hand, periodontitis can influence the development and state of chronic systemic inflammation, through the aberrant increase in proinflammatory cytokines, such as IL-1, IL-6 and TNF-, affecting endothelial function, and substantially contributing to the development of insulin resistance, causing a homeostatic imbalance in blood glucose regulation ( Figure 1 TNF- plays a crucial role in regulating the expression of endocan, a soluble proteoglycan that is highly produced by vascular endothelium during endothelial activation and inflammatory processes (Sarrazin et al., 2006)
It is generated in small amounts by the stomach lining and has been shown to have both healing and regenerative abilities
or collapse
Fatigue or Dizziness: Transient lethargy has been noted early on, possibly from metabolic shifts or inflammation reduction
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