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Altschul, S
Treatment of mice with DS-induced colitis (resembling human ulcerative colitis) with the human GLP-2 analog h(Gly 2 )GLP, twice daily for 10 days, reverses weight loss independent on food intake, decreases interleukin-1 expression and increased colon length, crypt depth, and mucosal area compared to treatment with saline (Drucker et al., 1999)
Realworld retrospective study in elderly patients aged 65 years and older with type 2 diabetes mellitus treated with daily oral semaglutide (SEMAelderly)
Years later, some patients who had lost significant weight were struggling with fatigue, weakness, declining bone density, and reduced metabolic rate
It describes three evidence-supported pathways: continuing semaglutide at the lowest effective dose, structured tapering paired with intensive behavioral support, or transitioning to alternative peptide compounds if semaglutide becomes inaccessible
