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Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity

The evidence: Extends lifespan and reduces frailty in mice

second, focusing on high-risk cohorts, such as patients with MASH-related compensated cirrhosis, using dynamic contrast-enhanced ultrasound (DCE-US) to monitor de novo nodule emergence and evolution (e.g., arterial phase hyperenhancement) as surrogate endpoints for preliminary chemopreventive assessment