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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)

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For example, variant X(GD_L)c.3 (later renamed X(GD_L)f) had a catalytic efficiency of 0.004 M 1 s 1 , whereas the parent X(GD_L)c that lacked reversion and engineering showed no detectable activity on the FRET substrate (Fig

Studies in humans show that intracellular antioxidant levels rise by 4060% in the first week of treatment with glutathione injections