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Moreover, in a hyperglycemic ApoE gene knockout mouse model, liraglutide was found to inhibit atherosclerosis through an AMPK-independent mechanism, suggesting that GLP-1 receptor agonists may exert cardiovascular protective effects through multiple mechanisms ( FIGURE 3 Preliminary evidence also suggests that tirzepatide may confer cardiovascular benefits by improving lipid metabolism (e.g., lowering LDL cholesterol) and reducing inflammation (e.g., lowering C-reactive protein)

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