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A 2016 Health Canada technical report on drinking water found limited evidence that exposure to extremely alkaline water (pH greater than11) may cause skin or eye irritation
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In addition to downregulation of injury and inflammation-related pathways, GSEA also revealed suppression of adipogenesis-related pathways in the liver of GPR146-deficient mice, suggesting that GPR146 may promote hepatic steatosis via PPAR-mediated transcriptional programs (Fig
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